A Case of Myelin Oligodendrocyte Glycoprotein Antibody Disease Associated With Post-Dengue Transverse Presenting With Paraplegia and Urinary Retention

Abstract

Transverse myelitis is the inflammation of the spinal cord, which causes the is demyelination in a horizontal plane. Dengue virus is known to be associated with transverse myelitis para or post infectiously. Autoantibodies such as Aquaporin-4 autoantibodies and Myelin oligodendrocyte glycoprotein autoantibodies have been associated with transverse myelitis. However, the exact causal relationship is yet to be determined. We report a case of post-dengue fever transverse myelitis associated with myelin oligodendrocyte glycoprotein antibody disease. A 26-year-old previously healthy young man presented with acute urinary retention and paraplegia. He had a recent history of contracting dengue virus infection. He had a positive serology for antibodies against the dengue virus and imaging showed the inflammation of the spinal cord consistent with transverse myelitis. Further workup demonstrated the presence of Myelin oligodendrocyte glycoprotein autoantibodies. A diagnosis of Myelin oligodendrocyte glycoprotein antibody disease associated with post-dengue transverse myelitis was made. He was treated with high-dose methylprednisolone for 7 days followed by an oral tapping dose over 6 months. Follow-up examination and imaging showed subsequent improvement with complete recovery. Myelin oligodendrocyte glycoprotein antibody disease is a very less understood and rare complication of dengue virus infection. Further studies are required to determine the exact mechanism. Moreover, prompt diagnosis. treatment can result in early recovery and complete remission of the disease.