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In the vast majority of nations across the globe, coronary artery disease (CAD) remains the leading cause of mortality. It is among the most widely recognized global health concerns affecting both sexes. The worldwide impact of CAD is severe, and its consequences are particularly pronounced in countries with higher incidence rates. In Western nations, myocardial infarction outcomes are often linked to socioeconomic status, with those in lower socioeconomic positions disproportionately affected by the burden of this disease. Given the high rates of morbidity and mortality associated with acute myocardial infarction (MI), this condition continues to be a major focus of cardiovascular therapy. The present study sheds new light on the issue, as the findings differ from previous research due to demographic, nutritional, and lifestyle differences. The dissemination of these findings to the medical community will be critical to informing future research and better understanding how to recognize and treat hyperuricemia in ACS patients. This study has important implications for public health policy and clinical practice. By improving our understanding of the complex interplay between socioeconomic factors and cardiovascular health, we can develop more targeted interventions and improve outcomes for those at the highest risk of CAD and related conditions. This study was performed at the Cardiology Department of Khyber Teaching Hospital, Peshawar for six months, from 19th July 2022 to 19th January 2023. It was a cross-sectional study in which 360 male and female patients aged between 30-60 years were included with acute coronary syndrome. Clinical history, physical examination, and laboratory investigations, including troponin test and ECG results, were adequately monitored. At the time of admission, all patients’ blood samples were collected and biochemically analyzed to determine serum uric acid (SUA) levels at Khyber Teaching Hospital. Men with uric acid levels over 7 mg/dl and women with uric acid levels exceeding 6 mg/dl have hyperuricemia. This study reveals a mean age of 52 years with a SD ±11.74. 63 % of patients were male, and 37% were female. Moreover, 35% of patients had hyperuricemia, and 65% didn’t. Our study concludes that the frequency of hyperuricemia was 35% in patients presenting with acute coronary syndrome to the Cardiology Department of Khyber Teaching Hospital, Peshawar.