Examining the Autoimmune, Genetic, Environmental, and Microbial Aspects of the Complex Etiology of Inflammatory Bowel Diseases: A Comprehensive Review and Comparative Analysis

Abstract

Inflammatory Bowel Disease is an autoimmune disease of the Colon and or ileum. The exact cause of the disease is unknown but there are many factors that may predispose a person, worsen or improve the condition of the patient. These include genetic, environmental, autoimmune and bacterial factors. Here we briefly discus each one of these factors. We used databases including PubMed, Google Scholar, Scopus, and Web of Science to conduct a thorough literature search for our analysis of Inflammatory Bowel Disease (IBD). Screening researches, reviews, and meta-analyses from the previous two decades was part of our methodology. Articles that provided substantial new insights into the etiology, clinical presentation, and treatment approaches of IBD were the main focus of our inclusion criteria. In order to compile the state of knowledge and new directions in IBD research, we also carefully gathered data from citations and cross-referenced them to locate more pertinent studies. Inflammatory bowel disease is an autoimmune condition the exact cause of which is still unknown. This highlights the intricate relationship that exists between the immune system, environment, and gut microbiota, as well as the need for advancements in the field to identify the precise cause of the illness under consideration and develop a treatment plan for it.